Glyoxalase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-{{STRUCTURE_1qin|  PDB=1qin  | SIZE=400| SCENE= |right|CAPTION=Human glyoxalase I dimer complex with glutathione derivative, [[1qin]] }}
+<StructureSection load='' size='350' side='right' scene='50/508460/Cv/1' caption='Human glyoxalase I dimer complex with glutathione derivative and Zn+2 ion (grey) [[1qin]]'>
-'''Glyoxalase''' (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism.  GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.  GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate.  GLO2 exists as cytosolic and mitochondrial forms.  For details on GLO2 see [[Leishmania infantum Glyoxalase II]].
-==3D structures of glyoxalase==
+== Function ==
+'''Glyoxalase''' (GLO) is part of the glyoxalase system which detoxifies the highly toxic methylglyoxal and other aldehydes produced by metabolism<ref>PMID:10066594</ref>. <br />
+* '''GLO1''' or '''lactoylglutathione lyase''' catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.<br />
+* '''GLO2''' is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate.  GLO2 exists as cytosolic and mitochondrial forms.  For details on GLO2 see [[Leishmania infantum Glyoxalase II]].
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+== Relevance ==
+GLO1 is a target for drugs against bacteria, protozoans and cancer<ref>PMID:8277832</ref>.  The GLO system is a focus of research on metabolic control and prevention of vascular complications in diabetes and obesity<ref>PMID:21335095</ref>.
-===Glyoxalase 1===
+== Structural highlights ==
-[[1bh5]] – hGLO (mutant) – human<br />
+<scene name='50/508460/Cv/5'>Human GLO1 active site contains Zn+2 atom</scene><ref>PMID:10521255</ref>. Water molecules are shown as red spheres.
-[[1fa8]] – EcGLO – ''Escherichia coli''<br />
-[[2c21]] – GLO – ''Leishmania major''<br />
-[[1fro]] – hGLO + benzyl glutathione<br />
-[[1qin]], [[1qip]] - hGLO + glutathione derivative<br />
-[[1f9z]], [[1fa5]], [[1fa6]], [[1fa7]] – EcGLO + metal <br />
-[[2za0]] – GLO + methyl gerfelin – mouse<br />
-[[3hdp]] – GLO + Ni – ''Clostridium acetobutylicum''
-===Glyoxalase 2===
+==3D structures of glyoxalase==
+[[Glyoxalase 3D structures]]
-[[1xm8]] – GLO – ''Arabidopsis thaliana''<br />
+ </StructureSection>
-[[2p18]] - LiGLO – ''Leishmania infantum''<br />
-[[1qh3]] – hGLO + actate + cacodylate<br />
-[[1qh5]] – hGLO + glutathione derivative<br />
-[[2p1e]] – LiGLO + lactate
+== References ==
+<references/>
 [[Category:Topic Page]]