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| {{STRUCTURE_1bs1| PDB=1bs1 | SIZE=400| SCENE= |right| CAPTION=Dethiobiotin synthetase complex with dethiobiotin, ADP and Mg+2 ion, [[1bs1]] }}
| | <StructureSection load='1a82' size='450' side='right' caption='Dethiobiotin synthetase complex with dethiobiotin, ATP and Mg+2 ion (green) (PDB entry [[1a82]])' scene='49/493028/Cv/1'> |
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| '''Dethiobiotin synthetase''' (DTBS) catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate. | |
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| ==3D dethiobiotin synthetase==
| | '''Dethiobiotin synthetase''' (DTBS) or '''ATP-depenent dethiobiotin synthetase''' catalyzes the first ring closure in the biotin synthesis. The reaction transforms 7,8-diaminononanoate (DAN), ATP and CO2 to dethiobiotin (DTB), ADP and phosphate.<ref>PMID:4921568</ref> |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | == Structural highlights == |
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| [[1dbs]], [[1dts]], [[1byi]] – EcDTBS – ''Escherichia coli''<br />
| | The <scene name='49/493028/Cv/5'>active site contains the substrate (DAN), Mg+2 ion and ATP</scene>.<ref>PMID:9576910</ref> |
| [[2qmo]] – HpDTBS – ''Helicobacter pylori''<br />
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| [[3fgn]] – MtDTBS – ''Mycobacterium tuberculosis''<br />
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| [[3of5]] – DTBS – ''Francicella tularensis''
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| '''DTBS binary complex'''
| | ==3D dethiobiotin synthetase== |
| | | [[Dethiobiotin synthetase 3D structures]] |
| [[3fmf]] – MtDTBS + DAN<br />
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| [[1dad]] – EcDTBS + ADP<BR />
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| [[1dae]] - EcDTBS + nonanedioate derivative<br />
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| [[3fmi]] – MtDTBS + aminopelargonic acid<br />
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| [[1dai]] - EcDTBS + DAN
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| '''DTBS ternary complex'''
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| [[3qxc]] - HpDTBS + Mg + ATP<BR />
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| [[1daf]] - EcDTBS + DAN + ADP<BR />
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| [[1dag]] - EcDTBS + DAN + ATP derivative<br />
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| [[3qxj]] - HpDTBS + Mg + ATP<BR />
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| [[3qxs]] - HpDTBS + Mg + phosphoaminophosphonic acid
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| '''DTBS quaternary complex'''
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| [[1dah]] - EcDTBS + DAN + Mn + ATP derivative<br />
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| [[1bs1]] - EcDTBS + DTB + Mg + ADP<BR />
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| [[1a82]] - EcDTBS + DAN + Mg + ATP<BR /> | |
| [[3fpa]] - MtDTBS + DTB + Mg + phosphate <br />
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| [[3mle]] - HpDTBS + Mg + phosphate + ADP<BR />
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| [[3qy0]] - HpDTBS + Mg + phosphate + GDP<BR />
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| '''DTBS higher complexes'''
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| [[1dam]] - EcDTBS + DTB + Mg + phosphate + ADP<BR />
| | </StructureSection> |
| [[1dak]] - EcDTBS + DAN + mixed anhydride + Mg + phosphate + ADP<BR />
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| [[3qxh]] - HpDTBS + aminooctanoic acid + Mg + phosphate + ADP<BR />
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| [[3qxx]] - HpDTBS + aminooctanoic acid + Mg + phosphate + GTP<BR />
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| | == References == |
| | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |