CD2-associated protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='2j6o' size='350' side='right' caption='Structure of human CD2AP SH3 domain 1 (grey) complex with E3 ubiquitin ligase peptide (pink) (PDB entry [[2j6f]])' scene=''>
+<StructureSection load='2j6o' size='350' side='right' caption='Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (magenta) (PDB entry [[2j6o]])' scene='56/569738/Cv/1'>
-'''CD2-associated protein''' (CD2AP) called also '''CMS''', is a scaffolding protein which regulates actin cytoskeleton.  CD2AP SH3 domain interacts with actin and a variety of membrane proteins.  CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.
+__TOC__
-==3D structures of CD2-associated protein==
+== Function ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+'''CD2-associated protein''' (CD2AP) called also '''CMS''', is a scaffolding protein which regulates actin cytoskeleton.  CD2AP SH3 domain interacts with actin and a variety of membrane proteins.  CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.<ref>PMID:12354621</ref><ref>PMID:17020880</ref>
-===CD2AP SH3 domain 1===
+== Disease ==
-[[2j6k]] – hCD2AP – human <br />
+Haploinsufficiency of CD2AP is associated with susceptibility of glomerular disease
-[[2krm]] – mCD2AP – mouse - NMR <br />
-[[2j6f]] – hCD2AP + E3 ubiquitin protein ligase peptide  <br />
-[[2j6o]], [[2j7i]] – hCD2AP + CD2 peptide  <br />
-[[2mcn]] - mCD2AP + ubiquitin   <br />
-===CD2AP SH3 domain 2===
+==3D structures of CD2-associated protein==
+[[CD2-associated protein 3D structures]]
-[[2fei]] – hCD2AP – NMR<br />
-[[2krn]] – mCD2AP– NMR<br />
-[[3u23]] - hCD2AP + RIN3 proline-rich peptide<br />
-===CD2AP SH3 domain 3===
-[[2jte]], [[2kro]] – mCD2AP - NMR<br />
-[[2lz6]] – hCD2AP + ubiquitin - NMR<br />
-===CD2AP proline-rich domain===
-[[3lk4]], [[3aa6]] – hCD2AP + CapZ<br />
+</StructureSection>
+== References ==
+<references/>
 [[Category: Topic Page]]