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| <StructureSection load='' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/3' pspeed='8'> | | <StructureSection load='' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/4' pspeed='8'> |
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| == Function == | | == Function == |
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| == Structural highlights == | | == Structural highlights == |
| The <scene name='75/750267/Cv/1'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>. These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/2'>Phosphoserine binding</scene>. | | The <scene name='75/750267/Cv/5'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>. These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/6'>Phosphoserine binding</scene>. |
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| </StructureSection>
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| ==3D structures of BRCA== | | ==3D structures of BRCA== |
| | [[BRCA 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *BRCA1
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| **[[4ofb]], [[4y18]], [[4y2g]], [[4u4a]], [[4jlu]], [[4ifi]], [[4igk]], [[3k0h]], [[3k0k]], [[3coj]], [[1y98]], [[1t15]], [[1t29]], [[1t2v]] - hBRCA1 BRCT1 domain + peptide inhibitor - human<br />
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| **[[3pxa]], [[3pxb]], [[3pxc]], [[3pxd]], [[3pxe]], [[3k15]], [[3k16]] - hBRCA1 BRCT1 domain (mutant) + peptide inhibitor<br />
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| **[[1jnx]] - hBRCA1 BRCT domain<br />
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| **[[2ing]], [[1t2u]], [[1n5o]] - hBRCA1 BRCT1 domain (mutant)<br />
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| **[[1oqa]] - hBRCA1 BRCT-C domain - NMR<br />
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| **[[1l0b]] - BRCA1 BRCT domain - rat<br />
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| **[[2n9e]] - hBRCA1 SUMO-interacting motif + small ubiquitin-related modifier - NMR<br />
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| **[[4mkf]], [[4mkg]] - hBRCA1 SUMO-interacting motif - NMR<br />
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| **[[1jm7]] - hBRCA1 Ring domain + BARD1 ring domian - NMR<br />
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| *BRCA2
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| **[[1iyj]], [[1miu]] – hBRCA2 residues 2335-3151 + DSS1<br />
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| **[[1mje]] – hBRCA2 residues 2335-3151 + DSS1 + ssDNA<br />
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| **[[1n0w]] – hBRCA2 BRC repeat 4 + RAD51 + linker<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |