BRCA: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''BRCA1''' and '''BRCA2''' or '''breast cancer type 1 susceptibility ... |
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<StructureSection load='' size='450' side='right' caption='Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code [[3coj]]) ' scene='75/750267/Cv/4' pspeed='8'> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
'''BRCA1''' and '''BRCA2''' or '''breast cancer type 1 susceptibility protein''' are tumor suppressors which help repair damaged DNA. | '''BRCA1''' and '''BRCA2''' or '''breast cancer type 1 susceptibility protein''' are tumor suppressors which help repair damaged DNA. For more details see: | ||
*[[RING Finger Domain of BRCA1 and BARD1 Heterodimer]]. | |||
*[[Mutations in BRCA1/BARD1 RING-domain heterodimer]]. | |||
*[[Mutations in Brca1 BRCT Domains]]. | |||
== Disease == | == Disease == | ||
Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers<ref>PMID:20301425</ref>. | Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers<ref>PMID:20301425</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
The <scene name='75/750267/Cv/5'>phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains</scene>. These domains contain most of the mutations seen in BRCA1<ref>PMID:18452305</ref>. <scene name='75/750267/Cv/6'>Phosphoserine binding</scene>. | |||
==3D structures of BRCA== | |||
[[BRCA 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||