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<StructureSection load='1joi' size='450' side='right' caption='Structure of azurin containing Cu+2 ion (PDB code [[1joi]]).' scene='59/593967/Cv/1'>
<StructureSection load='1joi' size='350' side='right' caption='Structure of azurin containing Cu+2 ion (PDB code [[1joi]]).' scene='59/593967/Cv/1'>


== Function ==
== Function ==


'''Azurin''' (AZ) is a blue copper protein.  AZ mediates electron transfer and contains type I copper center.
'''Azurin''' (AZ) is a blue copper protein.  AZ mediates electron transfer and contains type I copper center.<br />
For details see [[Intramolecular Electron Transfer in Azurin]].


== Relevance ==
== Relevance ==
Line 11: Line 12:
== Structural highlights ==
== Structural highlights ==


<scene name='59/593967/Cv/2'>AZ active Cu binding site is shown here</scene>. <ref>PMID:8109977</ref>
<scene name='59/593967/Cv/3'>AZ active Cu binding site is shown here</scene>. <ref>PMID:8109977</ref>
</StructureSection>
==3D structures of cAMP-dependent protein kinase==
 
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Azurin
 
**[[1e65]] – PaAZ – ''Pseudomonas aeruginosa''<br />
 
*Cu+2 containing azurin
 
**[[1azu]], [[1azr]], [[4azu]], [[5azu]], [[1azn]], [[1cc3]], [[1e5y]], [[1e5z]], [[1jze]], [[2ft6]], [[2ft7]], [[2ft8]], [[2fta]], [[3fs9]], [[3fsa]], [[3fsv]], [[3fsw]], [[3fsz]], [[3ft0]]  – PaAZ  <br />
**[[3fq2]], [[4hip]], [[4qkt]]  – PaAZ  (mutant)<br />
**[[1cuo]], [[1uat]] – AZ  – ''Methylomonas''<br />
**[[1joi]] – PfAZ  – ''Pseudomonas fluorrescens''<br />
**[[1nwo]] – PpAZ  – ''Pseudomonas putida''<br />
**[[1nwp]] – PpAZ  + Zn+2<br />
**[[2aza]], [[1azb]], [[1azc]], [[1rkr]] – AxAZ  – ''Achromobacter xylosoxidans''<br />
**[[1dyz]], [[1dz0]], [[2ccw]] – AZ  II – ''Alcaligenes xylosoxidans''<br />
**[[2azu]], [[3azu]], [[1ils]], [[1ilu]], [[2tsa]], [[2tsb]], [[1etj]], [[1ag0]], [[1ezl]], [[1jvo]], [[1gr7]], [[1xb3]], [[1xb6]], [[1xb8]], [[2ghz]], [[2hx7]], [[2oj1]], [[3in0]], [[3fpy]], [[3fq1]],  [3fq2]], [[3fqy]], [[3in2]], [[3jt2]], [[3jtb]], [[3np3]], [[3np4]], [[3oqr]], [[3n2j]], [[3u25]], [[4hhw]], [[4mfh]], [[4ko5]], [[4ko6]], [[4ko7]], [[4ko9]], [[4kob]], [[4koc]], [[4bww]] – PaAZ (mutant)  <br />
**[[1jvl]], [[2idf]] – PaAZ (mutant)  + Ni+2<br />
**[[1uri]], [[1a4a]], [[1a4b]], [[1a4c]] – AdAZ (mutant)  <br />
**[[2h3x]], [[2h47]], [[2iaa]] – AZ  + aromatic amine dehydrogenase – ''Alcaligenes faecalis''<br />
 
*Cu+2 containing lanthanide-modified azurin
 
**[[1bex]], [[1jzi]], [[1jze]], [[1jzf]], [[1jzj]], [[1jzh]] – PaAZ <br />
**[[2i7s]], [[2fnw]], [[2i7o]], [[3ibo]], [[4hhg]], [[4k9j]] – PaAZ (mutant)  <br />
 
*Cu+1 containing azurin
 
**[[1jzg]] – PaAZ  <br />
**[[1r1c]], [[2gi0]], [[1i53]], [[2hx8]], [[2hx9]], [[2hxa]], [[2xv0]], [[2xv2]], [[2xv3]] – PaAZ (mutant)  <br />
 
*Other metals-containing azurin
 
**[[1aiz]] – AdAZ + Cd+2 – ''Achromobacter denitrificans'' <br />
**[[1nzr]] – PaAZ (mutant) + Ni+2 <br />
**[[1vlx]] – PaAZ + Co+2 <br />
**[[1e67]] – PaAZ + Zn+2<br />
**[[2iwe]] – PaAZ (mutant) + Zn+2<br />
**[[3ay2]] – AZ (mutant) + Zn+2 – ''Neisseria Gonorhoeae''<br />
**[[3uge]] – PaAZ + Ag+1 <br />
**[[4hz1]] – PaAZ + Fe+2<br />
**[[4qlw]] – PaAZ (mutant) + Fe+2<br />
**[[4jkn]] – PaAZ + Hg+2<br />
 
}}
 
 
 
 
 
 
 


==3D structures of azurin==
[[Azurin 3D structures]]


</StructureSection>




Latest revision as of 12:08, 31 March 2019


Function

Azurin (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center.

For details see Intramolecular Electron Transfer in Azurin.

Relevance

AZ was found to be a novel anticancer agent. Following the entry of the P. aeruginosa bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.

Structural highlights

. [1]

3D structures of azurin

Azurin 3D structures


Structure of azurin containing Cu+2 ion (PDB code 1joi).

Drag the structure with the mouse to rotate


ReferencesReferences

  1. ↑ Zhu DW, Dahms T, Willis K, Szabo AG, Lee X. Crystallization and preliminary crystallographic studies of the crystals of the azurin Pseudomonas fluorescens. Arch Biochem Biophys. 1994 Feb 1;308(2):469-70. PMID:8109977 doi:http://dx.doi.org/10.1006/abbi.1994.1066

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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