ATPase family AAA domain-containing protein 2: Difference between revisions
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<StructureSection load='4tyl' size='340' side='right' caption=' | <StructureSection load='4tyl' size='340' side='right' caption='Human ATAD2A bromodomain comples with benzimidazol derivative inhibitor and Cl- ions (green) (PDB code [[4tyl]])' scene='80/800695/Cv/1'> | ||
== Function == | == Function == | ||
'''ATPase family AAA domain-containing protein 2''' (ATAD2) catalyzes the addition of H2O to ATP to produce ADP and phosphate. ATAD2 may be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes<ref>PMID:17998543</ref>. | '''ATPase family AAA domain-containing protein 2''' (ATAD2) catalyzes the addition of H2O to ATP to produce ADP and phosphate. ATAD2 may be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes<ref>PMID:17998543</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
<scene name='80/800695/Cv/3'>Benzimidazol derivative inhibitor binds within ATAD2A bromodomain ε-N-acetyllysine recognition site</scene> on histone proteins (Kac binding site) and interacts with the protein via hydrogen bond and hydrophobic interactions<ref>PMID:25314628</ref>. Water molecules are shown as red spheres. | |||
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==3D structures of ATPase family AAA domain-containing protein 2== | ==3D structures of ATPase family AAA domain-containing protein 2== | ||
[[ATPase family AAA domain-containing protein]] | |||
</StructureSection> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
Latest revision as of 12:02, 27 March 2019
FunctionATPase family AAA domain-containing protein 2 (ATAD2) catalyzes the addition of H2O to ATP to produce ADP and phosphate. ATAD2 may be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes[1]. RelevanceOverexpression of ATAD2 has been linked to breast cancer[2], hepatocellular carcinoma[3] and lung adenocarcinoma[4]. Structural highlightson histone proteins (Kac binding site) and interacts with the protein via hydrogen bond and hydrophobic interactions[5]. Water molecules are shown as red spheres. 3D structures of ATPase family AAA domain-containing protein 2ATPase family AAA domain-containing protein
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ReferencesReferences
- ↑ Zou JX, Revenko AS, Li LB, Gemo AT, Chen HW. ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18067-72. Epub 2007 Nov 12. PMID:17998543 doi:http://dx.doi.org/10.1073/pnas.0705814104
- ↑ Hsia EY, Kalashnikova EV, Revenko AS, Zou JX, Borowsky AD, Chen HW. Deregulated E2F and the AAA+ coregulator ANCCA drive proto-oncogene ACTR/AIB1 overexpression in breast cancer. Mol Cancer Res. 2010 Feb;8(2):183-93. doi: 10.1158/1541-7786.MCR-09-0095. Epub, 2010 Feb 2. PMID:20124470 doi:http://dx.doi.org/10.1158/1541-7786.MCR-09-0095
- ↑ Yang J, Huang J, Luo L, Chen Z, Guo Y, Guo L. Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma. Cancer Cell Int. 2014 Apr 4;14:33. doi: 10.1186/1475-2867-14-33. eCollection, 2014. PMID:24708861 doi:http://dx.doi.org/10.1186/1475-2867-14-33
- ↑ Zhang Y, Sun Y, Li Y, Fang Z, Wang R, Pan Y, Hu H, Luo X, Ye T, Li H, Wang L, Chen H, Ji H. ANCCA protein expression is a novel independent poor prognostic marker in surgically resected lung adenocarcinoma. Ann Surg Oncol. 2013 Dec;20 Suppl 3:S577-82. doi: 10.1245/s10434-013-3027-1. Epub, 2013 Jun 18. PMID:23775406 doi:http://dx.doi.org/10.1245/s10434-013-3027-1
- ↑ Harner MJ, Chauder BA, Phan J, Fesik SW. Fragment-based screening of the bromodomain of ATAD2. J Med Chem. 2014 Oct 14. PMID:25314628 doi:http://dx.doi.org/10.1021/jm501035j