Atlastin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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+<StructureSection load='4ido' size='350' side='right' caption='Structure of human atlastin cytoplasmic domain complex with GDP and AlF4 (PDB code [[4ido]]).' scene='59/590828/Cv/7'>
-<StructureSection load='3q5e' size='340' side='right' caption='Structure of human atlastin cytoplasmic domain complex with GDP (PDB code [[3q5e]]).' scene=''>
 == Function ==
-'''Atlastin''' (ATN) is a GTPase and a Golgi body transmembrane protein.  ATN was shown to be required in membrane fusion and ER formation in ''Drosophila melanogaster''.
+'''Atlastin''' (ATN) is a GTPase and a Golgi body transmembrane protein.  ATN was shown to be required in membrane fusion and ER formation in ''Drosophila melanogaster''.<ref name="Ad">PMID:23334294</ref>
 == Disease ==
-Defects in the ATN gene are a cause of spastic paraplegia type 3.
+Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D.  Mutations in ATL-3 affect multiple ER-related pathways<ref>PMID:30666337</ref>.
-== Relevance ==
 == Structural highlights ==
+*<scene name='59/590828/Cv/6'>GDP/AlF4 binding site</scene> from human atlastin (PDB code [[4ido]]).<ref name="Ad">PMID:23334294</ref> Water molecules shown as red spheres.
 ==3D structures of atlastin==
+[[Atlastin 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-[[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hATN cytoplasmic domain + GDP – human<br />
-[[4idn]] – hATN cytoplasmic domain + GNP <br />
-[[4idp]] – hATN cytoplasmic domain (mutant) + GNP <br />
-[[4ido]] – hATN cytoplasmic domain + GDP + AlF4<br />
-[[4idq]] – hATN cytoplasmic domain (mutant) + GDP + AlF4<br />
 == References ==
 <references/>
 [[Category: Topic Page]]