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| [[Image:1z1g.png|left|200px|thumb|Crystal Structure of Enterobacteria phage λ integrase [[1z1g]]]]
| | <StructureSection load='' size='400' side='right' scene='44/443479/Cv/2' caption='Se-Met Enterobacteria phage λ integrase:DNA tetramer complex (Holiday Junction) [[1z1g]]' pspeed='8'> |
| {{STRUCTURE_1z1g| PDB=1z1g | SIZE=400| SCENE=Phage_integrase/Cv/1 |right|CAPTION= Se-Met Enterobacteria phage λ integrase:DNA tetramer complex (Holiday Junction) [[1z1g]] }}
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| | '''Phage integrase''' (PIN) mediates recombination between DNA recognition sequences - the phage attachment site attP and the bacterial attachment site attB<ref>PMID:14687564</ref>. The '''Tyrosine family PIN''' uses a catalytic tyrosine to mediate strand cleavage while the '''Serine family PIN''' uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria. |
| | *The biological assembly of Enterobacteria phage λ integrase is <scene name='44/443479/Cv/3'>homotetramer</scene>. |
| | </StructureSection> |
| | == 3D Structures of phage integrase see [[Retroviral Integrase]]== |
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| | | == References == |
| | | <references/> |
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| '''Phage integrase''' (PIN) mediate recombination between DNA recognition sequences - the phage attP and the bacterial attB. The Tyrosine family PIN uses a catalytic tyrosine to mediate strand cleavage while the Serine family PIN uses a serine residue. The High-Pathogenicity Island (HPI) is a genomic island essential for virulence of the family of Enterobacteria.
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| {{TOC limit|limit=2}}
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| == 3D Structures of phage integrase == | |
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| ''Update June 2011''
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| [[3nrw]] – PIN/site-specific recombinase N-terminal – ''Haloarcula marismortui''<br />
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| [[3jtz]] – PIN arm-type binding domain – ''Yersinia pestis''<br />
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| [[3ju0]] – HPI PIN arm-type binding domain – ''Pectobacterium atrosepticum''<br />
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| [[2kkp]] – PIN SAM-like domain – ''Moorella thermoacetica'' – NMR<br />
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| [[2kkv]] – PIN fragment – ''Salmonella enterica'' – NMR<br />
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| [[2khq]] - PIN fragment – ''Staphylococcus saprophyticus'' – NMR<br />
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| [[2wcc]] – λPIN DBD+ DNA – Enterobacteria phage λ - NMR<br />
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| [[1kjk]] – λPIN N-terminal - NMR<br />
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| [[2oxo]], [[1z19]], [[1z1b]] - λPIN core binding domain + DNA<br />
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| [[1ae9]] - λPIN catalytic core domain (mutant) <br />
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| [[1z1g]] – λPIN + DNA (Holliday junction)<br />
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| [[1p7d]] – λPIN fragment + DNA <br />
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| [[3bvp]] – PIN catalytic core domain – Lactococcus phage TP101-1<br />
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| [[1aih]] - PIN catalytic core domain – Haemophilus phage HP1<br />
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| [[2khv]], [[2kj5]] – PIN residues 102-199 – ''Nitrosospira multiformis'' - NMR
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |