View source for 8tvl


==Plasminogen binding group A streptococcus M-like protein from AP53 bound to human plasminogen==
<StructureSection load='8tvl' size='340' side='right'caption='[[8tvl]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8tvl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TVL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tvl OCA], [https://pdbe.org/8tvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tvl RCSB], [https://www.ebi.ac.uk/pdbsum/8tvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tvl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PAM_STRPY PAM_STRPY] Binds to human plasminogen (and plasmin) via its kringle repeats. Also binds to albumin, immunoglobulin G and fibrinogen. Could provide the bacteria with a mechanism for invasion, as streptococcal-bound plasmin could permit tissue penetration.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus pyogenes]]
[[Category: Castellino FJ]]
[[Category: McCann NR]]
[[Category: Readnour BM]]
[[Category: Tjia-Fleck SK]]