View source for 8fix


==Cryo-EM structure of E. coli RNA polymerase backtracked elongation complex harboring a terminal mismatch==
<StructureSection load='8fix' size='340' side='right'caption='[[8fix]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8fix]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Escherichia_phage_Lambda Escherichia phage Lambda]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FIX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fix OCA], [https://pdbe.org/8fix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fix RCSB], [https://www.ebi.ac.uk/pdbsum/8fix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fix ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059]

==See Also==
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Escherichia phage Lambda]]
[[Category: Large Structures]]
[[Category: Bustamante C]]
[[Category: Canari C]]
[[Category: Florez Ariza A]]
[[Category: Grob P]]
[[Category: Nogales E]]
[[Category: Tong A]]
[[Category: Wee L]]