View source for 7ulx


==Human DDAH1 soaked with its inhibitor N4-(4-chloropyridin-2-yl)-L-asparagine==
<StructureSection load='7ulx' size='340' side='right'caption='[[7ulx]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ulx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ULX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ULX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.707&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NQ6:(2~{S})-2-azanyl-4-oxidanylidene-4-(pyridin-2-ylamino)butanoic+acid'>NQ6</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ulx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ulx OCA], [https://pdbe.org/7ulx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ulx RCSB], [https://www.ebi.ac.uk/pdbsum/7ulx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ulx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DDAH1_HUMAN DDAH1_HUMAN] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Butrin A]]
[[Category: Fast W]]
[[Category: Liu D]]
[[Category: Tuley A]]
[[Category: Zheng Y]]