Human DDAH1 soaked with its inhibitor N4-(4-chloropyridin-2-yl)-L-asparagineHuman DDAH1 soaked with its inhibitor N4-(4-chloropyridin-2-yl)-L-asparagine

Structural highlights

7ulx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.707Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DDAH1_HUMAN Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

7ulx, resolution 1.71Å

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OCA