View source for 7qu4


==Recombinant Human Fetal Hemoglobin mutant - alpha subunit mutations K11E,K56E,N78D,K90E==
<StructureSection load='7qu4' size='340' side='right'caption='[[7qu4]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7qu4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QU4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qu4 OCA], [https://pdbe.org/7qu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qu4 RCSB], [https://www.ebi.ac.uk/pdbsum/7qu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qu4 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/HBG2_HUMAN HBG2_HUMAN] Hereditary persistence of fetal hemoglobin - beta-thalassemia;Hereditary persistence of fetal hemoglobin - sickle cell disease;Hemoglobinopathy Toms River. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/HBG2_HUMAN HBG2_HUMAN] Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

==See Also==
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bulow L]]
[[Category: Kettisen K]]
[[Category: Nyblom M]]