View source for 5f4m


==Protruding domain of GII.17 norovirus Kawasaki323==
<StructureSection load='5f4m' size='340' side='right'caption='[[5f4m]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5f4m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_13-BH-1/2013/GII.17 Norovirus 13-BH-1/2013/GII.17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F4M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f4m OCA], [https://pdbe.org/5f4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f4m RCSB], [https://www.ebi.ac.uk/pdbsum/5f4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f4m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0A7CJV4_9CALI A0A0A7CJV4_9CALI] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Recent reports suggest that human GII.17 noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014/15 suggested that surface exposed substitutions on the uppermost part of the P domain might have generated a novel 2014/15 GII.17 variant.

Structural evolution of the emerging 2014/15 GII.17 noroviruses.,Singh BK, Koromyslova A, Hefele L, Gurth C, Hansman GS J Virol. 2015 Dec 23. pii: JVI.03119-15. PMID:26699640<ref>PMID:26699640</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5f4m" style="background-color:#fffaf0;"></div>

==See Also==
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Norovirus 13-BH-1/2013/GII 17]]
[[Category: Hansman GS]]
[[Category: Singh BK]]