5f4m

From Proteopedia
Jump to navigation Jump to search

Protruding domain of GII.17 norovirus Kawasaki323Protruding domain of GII.17 norovirus Kawasaki323

Structural highlights

5f4m is a 2 chain structure with sequence from Norovirus 13-BH-1/2013/GII.17. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.27Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A0A7CJV4_9CALI

Publication Abstract from PubMed

Recent reports suggest that human GII.17 noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014/15 suggested that surface exposed substitutions on the uppermost part of the P domain might have generated a novel 2014/15 GII.17 variant.

Structural evolution of the emerging 2014/15 GII.17 noroviruses.,Singh BK, Koromyslova A, Hefele L, Gurth C, Hansman GS J Virol. 2015 Dec 23. pii: JVI.03119-15. PMID:26699640[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. Singh BK, Koromyslova A, Hefele L, Gurth C, Hansman GS. Structural evolution of the emerging 2014/15 GII.17 noroviruses. J Virol. 2015 Dec 23. pii: JVI.03119-15. PMID:26699640 doi:http://dx.doi.org/10.1128/JVI.03119-15

5f4m, resolution 2.27Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA