View source for 4xxv


==Crystal structure of 3-isopropylmalate dehydrogenase from Burkholderia thailandensis in complex with NAD==
<StructureSection load='4xxv' size='340' side='right'caption='[[4xxv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4xxv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_thailandensis_E264 Burkholderia thailandensis E264]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XXV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xxv OCA], [https://pdbe.org/4xxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xxv RCSB], [https://www.ebi.ac.uk/pdbsum/4xxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xxv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LEU3_BURTA LEU3_BURTA] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]

==See Also==
*[[Isopropylmalate dehydrogenase|Isopropylmalate dehydrogenase]]
__TOC__
</StructureSection>
[[Category: Burkholderia thailandensis E264]]
[[Category: Large Structures]]