View source for 4o2l


==Structure of Mus musculus Rheb G63A mutant bound to GTP==
<StructureSection load='4o2l' size='340' side='right'caption='[[4o2l]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4o2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O2L FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o2l OCA], [https://pdbe.org/4o2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o2l RCSB], [https://www.ebi.ac.uk/pdbsum/4o2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o2l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHEB_MOUSE RHEB_MOUSE] Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity (By similarity).

==See Also==
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ho J]]
[[Category: Ikura M]]
[[Category: Ishiyama N]]
[[Category: Marshall CB]]
[[Category: Mazhab-Jafari MT]]
[[Category: Stambolic V]]