View source for 4mtk


==Crystal structure of PA0091 VgrG1, the central spike of the Type VI Secretion System==
<StructureSection load='4mtk' size='340' side='right'caption='[[4mtk]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4mtk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MTK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.322&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mtk OCA], [https://pdbe.org/4mtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mtk RCSB], [https://www.ebi.ac.uk/pdbsum/4mtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mtk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VGR1A_PSEAE VGR1A_PSEAE] Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:21325275, PubMed:24794869). Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1 (PubMed:26894531). Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity (PubMed:30177742).<ref>PMID:21325275</ref> <ref>PMID:24794869</ref> <ref>PMID:26894531</ref> <ref>PMID:30177742</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Leiman PG]]
[[Category: Shneider MM]]
[[Category: Sycheva LV]]