View source for 4j74


==The 1.2A crystal structure of humanized Xenopus MDM2 with RO0503918 - a nutlin fragment==
<StructureSection load='4j74' size='340' side='right'caption='[[4j74]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4j74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J74 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I18:(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-METHYL-4,5-DIHYDRO-1H-IMIDAZOLE'>I18</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j74 OCA], [https://pdbe.org/4j74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j74 RCSB], [https://www.ebi.ac.uk/pdbsum/4j74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j74 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).

==See Also==
*[[MDM2 3D structures|MDM2 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Graves B]]
[[Category: Janson C]]
[[Category: Kammlott U]]
[[Category: Lukacs C]]