View source for 4glw


==DNA ligase A in complex with inhibitor==
<StructureSection load='4glw' size='340' side='right'caption='[[4glw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4glw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_P1031 Streptococcus pneumoniae P1031]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XT:7-METHOXY-6-METHYLPTERIDINE-2,4-DIAMINE'>0XT</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glw OCA], [https://pdbe.org/4glw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4glw RCSB], [https://www.ebi.ac.uk/pdbsum/4glw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4glw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DNLJ_STRZP DNLJ_STRZP] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.[HAMAP-Rule:MF_01588]

==See Also==
*[[DNA ligase 3D structures|DNA ligase 3D structures]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae P1031]]
[[Category: Chambovey A]]
[[Category: Lange R]]
[[Category: Prade L]]
[[Category: Tidten-Luksch N]]