View source for 4c45


==Crystal structure of human pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)==
<StructureSection load='4c45' size='340' side='right'caption='[[4c45]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4c45]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C45 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c45 OCA], [https://pdbe.org/4c45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c45 RCSB], [https://www.ebi.ac.uk/pdbsum/4c45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c45 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHS2_HUMAN PHS2_HUMAN] Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity).  Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Canning P]]
[[Category: Edwards A]]
[[Category: Kiyani W]]
[[Category: Kopec J]]
[[Category: Shrestha L]]
[[Category: Vollmar M]]
[[Category: Yue WW]]
[[Category: Von Delft F]]