View source for 3op3


==Crystal Structure of Cell Division Cycle 25C Protein Isoform A from Homo sapiens==
<StructureSection load='3op3' size='340' side='right'caption='[[3op3]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3op3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OP3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3op3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3op3 OCA], [https://pdbe.org/3op3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3op3 RCSB], [https://www.ebi.ac.uk/pdbsum/3op3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3op3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MPIP3_HUMAN MPIP3_HUMAN] Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.<ref>PMID:8119945</ref> 
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/3op3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3op3 ConSurf].
<div style="clear:both"></div>

==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Ball L]]
[[Category: Barr A]]
[[Category: Bountra C]]
[[Category: Edwards A]]
[[Category: Gileadi O]]
[[Category: Hatzos C]]
[[Category: Joachimiak A]]
[[Category: Johansson C]]
[[Category: Kim Y]]
[[Category: Knapp S]]
[[Category: Muniz J]]
[[Category: Savitsky P]]
[[Category: Vollmar M]]
[[Category: Weger A]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]