View source for 3ogl


==Structure of COI1-ASK1 in complex with JA-isoleucine and the JAZ1 degron==
<StructureSection load='3ogl' size='340' side='right'caption='[[3ogl]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3ogl]] is a 23 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OGL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.18&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7JA:N-({(1R,2S)-3-OXO-2-[(2Z)-PENT-2-EN-1-YL]CYCLOPENTYL}ACETYL)-L-ISOLEUCINE'>7JA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ogl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ogl OCA], [https://pdbe.org/3ogl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ogl RCSB], [https://www.ebi.ac.uk/pdbsum/3ogl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ogl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COI1_ARATH COI1_ARATH] Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses. Seems to not be required for meiosis. Required for the regulation of some genes induced by wounding, but not for all. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6). These SCF complexes play crucial roles in regulating response to jasmonate, and their interactions with the COP9 signalosome (CSN) appear to be important for their activity. Interacts with TIFY10A and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor. Involved in the regulation of plant gene expression during plant-pathogen interactions with Pseudomonas syringae and Alternaria brassicicola.<ref>PMID:9582125</ref> <ref>PMID:12244256</ref> <ref>PMID:10810145</ref> <ref>PMID:12172836</ref> <ref>PMID:12172031</ref> <ref>PMID:12445118</ref> <ref>PMID:12724535</ref> <ref>PMID:12805591</ref> <ref>PMID:14756769</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Ben-Nissan G]]
[[Category: Browse J]]
[[Category: He SY]]
[[Category: Hinds TR]]
[[Category: Howe GA]]
[[Category: Hsu F]]
[[Category: Mao H]]
[[Category: Rizo J]]
[[Category: Sharon M]]
[[Category: Sheard LB]]
[[Category: Tan X]]
[[Category: Withers J]]
[[Category: Zheng N]]