View source for Cyclic GMP-AMP synthase

<StructureSection load='4o67' size='350' side='right' caption='Structure of human cyclic GMP-AMP synthase complex with c-GAMP and Zn+2 (grey) ions (PDB code [[4o67]]). ' scene='59/591942/Cv/2'>

== Function ==

'''Cyclic GMP-AMP synthase''' (CGAS) binds to DNA and catalyzes cGAMP synthesis.  The cGAMP activates the type-I interferon pathway.  <ref>PMID:23258413</ref>

== Disease ==

Mice lacking CGAS are more vulnerable to lethal infection by DNA virus.

== Structural highlights ==

The <scene name='59/591942/Cv/4'>2'3'-cGAMP binds at the lower part of the cleft between the N-lobe and C-lobe of CGAS</scene>.<ref>PMID:24462292</ref>

==3D structures of cyclic GMP-AMP synthase==
[[Cyclic GMP-AMP synthase 3D structures]]

</StructureSection>

== References ==
<references/>

[[Category:Topic Page]]