View source for 8efs


==CryoEM of the soluble OPA1 tetramer from the apo helical assembly on a lipid membrane==
<StructureSection load='8efs' size='340' side='right'caption='[[8efs]], [[Resolution|resolution]] 9.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8efs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EFS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9.68&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8efs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8efs OCA], [https://pdbe.org/8efs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8efs RCSB], [https://www.ebi.ac.uk/pdbsum/8efs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8efs ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/OPA1_HUMAN OPA1_HUMAN] Autosomal dominant optic atrophy, classic form;Autosomal dominant optic atrophy plus syndrome. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/OPA1_HUMAN OPA1_HUMAN] Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317).[UniProtKB:P58281]<ref>PMID:16778770</ref> <ref>PMID:17709429</ref> <ref>PMID:18158317</ref> <ref>PMID:20185555</ref> <ref>PMID:20974897</ref> <ref>PMID:24616225</ref> <ref>PMID:28746876</ref>   Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.<ref>PMID:20038677</ref>   Isoforms that contain the alternative exon 4b (present in isoform 4 and isoform 5) are required for mitochondrial genome maintenance, possibly by anchoring the mitochondrial nucleoids to the inner mitochondrial membrane.<ref>PMID:20974897</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Canagarajah B]]
[[Category: Hinshaw JE]]
[[Category: Nyenhuis SB]]
[[Category: Stanton AE]]
[[Category: Strub MP]]
[[Category: Wu X]]
[[Category: Yim YI]]