View source for 8sze


==Crystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim==
<StructureSection load='8sze' size='340' side='right'caption='[[8sze]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8sze]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SZE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sze OCA], [https://pdbe.org/8sze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sze RCSB], [https://www.ebi.ac.uk/pdbsum/8sze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sze ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A3N4BLI0_YERPE A0A3N4BLI0_YERPE] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[ARBA:ARBA00025067][PIRNR:PIRNR000194]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Yersinia pestis]]
[[Category: Cherry S]]
[[Category: Ji X]]
[[Category: Shaw GX]]
[[Category: Tropea JE]]
[[Category: Waugh DS]]