8sze

Crystal structure of Yersinia pestis dihydrofolate reductase in complex with TrimethoprimCrystal structure of Yersinia pestis dihydrofolate reductase in complex with Trimethoprim

Structural highlights

8sze is a 2 chain structure with sequence from Yersinia pestis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A3N4BLI0_YERPE Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[ARBA:ARBA00025067][PIRNR:PIRNR000194]

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