View source for 3vx8


==Crystal structure of Arabidopsis thaliana Atg7NTD-Atg3 complex==
<StructureSection load='3vx8' size='340' side='right' caption='[[3vx8]], [[Resolution|resolution]] 3.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vx8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VX8 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vx6|3vx6]], [[3vx7|3vx7]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATG7, APG7, At5g45900, K15I22.10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH]), ATG3, APG3, At5g61500, K11J9.3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vx8 OCA], [http://pdbe.org/3vx8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vx8 RCSB], [http://www.ebi.ac.uk/pdbsum/3vx8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vx8 ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ATG7_ARATH ATG7_ARATH]] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process.<ref>PMID:12070171</ref>  [[http://www.uniprot.org/uniprot/ATG3_ARATH ATG3_ARATH]] E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). 

==See Also==
*[[Autophagy-related protein|Autophagy-related protein]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arath]]
[[Category: Fujioka, Y]]
[[Category: Matoba, K]]
[[Category: Noda, N N]]
[[Category: E1-e2 complex]]
[[Category: Ligase]]