View source for 2efg

[[Image:2efg.jpg|left|200px]]

 {{Structure
|PDB= 2efg |SIZE=350|CAPTION= <scene name='initialview01'>2efg</scene>, resolution 2.60&Aring;
|SITE= 
|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
|ACTIVITY= 
|GENE= 
}}

'''TRANSLATIONAL ELONGATION FACTOR G COMPLEXED WITH GDP'''


==Overview==
Elongation factor G (EF-G) catalyzes the translocation step of protein synthesis in bacteria, and like the other bacterial elongation factor, EF-Tu--whose structure is already known--it is a member of the GTPase superfamily. We have determined the crystal structure of EF-G--GDP from Thermus thermophilus. It is an elongated molecule whose large, N-terminal domain resembles the G domain of EF-Tu, except for a 90 residue insert, which covers a surface that is involved in nucleotide exchange in EF-Tu and other G proteins. The tertiary structures of the second domains of EF-G and EF-Tu are nearly identical, but the relative placement of the first two domains in EF-G--GDP resembles that seen in EF-Tu--GTP, not EF-Tu--GDP. The remaining three domains of EF-G look like RNA binding domains, and have no counterparts in EF-Tu.

==About this Structure==
2EFG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFG OCA]. 

==Reference==
The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution., Czworkowski J, Wang J, Steitz TA, Moore PB, EMBO J. 1994 Aug 15;13(16):3661-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8070396 8070396]
[[Category: Single protein]]
[[Category: Thermus thermophilus]]
[[Category: Czworkowski, J.]]
[[Category: Moore, P B.]]
[[Category: Steitz, T A.]]
[[Category: Wang, J.]]
[[Category: GDP]]
[[Category: elongation]]
[[Category: elongation factor]]
[[Category: gtp binding]]
[[Category: gtpase]]
[[Category: guanosine nucleotide binding]]
[[Category: protein synt factor]]
[[Category: ribosome]]
[[Category: translation]]
[[Category: translocase]]

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