View source for 1qqv

[[Image:1qqv.gif|left|200px]]

 {{Structure
|PDB= 1qqv |SIZE=350|CAPTION= <scene name='initialview01'>1qqv</scene>
|SITE= 
|LIGAND= 
|ACTIVITY= 
|GENE= 
}}

'''SOLUTION STRUCTURE OF THE HEADPIECE DOMAIN OF CHICKEN VILLIN'''


==Overview==
A growing family of F-actin-bundling proteins harbors a modular F-actin-binding headpiece domain at the C terminus. Headpiece provides one of the two F-actin-binding sites essential for filament bundling. Here, we report the first structure of a functional headpiece domain. The NMR structure of chicken villin headpiece (HP67) reveals two subdomains that share a tightly packed hydrophobic core. The N-terminal subdomain contains bends, turns, and a four-residue alpha-helix as well as a buried histidine residue that imparts a pH-dependent folding. The C-terminal subdomain is composed of three alpha-helices and its folding is pH-independent. Two residues previously implicated in F-actin-binding form a buried salt-bridge between the N and C-terminal subdomains. The rest of the identified actin-binding residues are solvent-exposed and map onto a unique F-actin-binding surface.

==About this Structure==
1QQV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QQV OCA]. 

==Reference==
NMR structure of an F-actin-binding "headpiece" motif from villin., Vardar D, Buckley DA, Frank BS, McKnight CJ, J Mol Biol. 1999 Dec 17;294(5):1299-310. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600386 10600386]
[[Category: Gallus gallus]]
[[Category: Single protein]]
[[Category: Buckley, D A.]]
[[Category: Frank, B S.]]
[[Category: McKnight, C J.]]
[[Category: Vardar, D.]]
[[Category: f-actin binding domain]]
[[Category: salt-bridge]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:41:29 2008''