View source for 1vgh

{{STRUCTURE_1vgh|  PDB=1vgh  |  SCENE=  }} 
===HEPARIN-BINDING DOMAIN FROM VASCULAR ENDOTHELIAL GROWTH FACTOR, NMR, 20 STRUCTURES===
{{ABSTRACT_PUBMED_9634701}}

==Disease==
[[http://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN]] Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:[http://omim.org/entry/603933 603933]]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. 

==Function==
[[http://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN]] Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.<ref>PMID:11427521</ref><ref>PMID:15520188</ref><ref>PMID:16489009</ref> 

==About this Structure==
[[1vgh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VGH OCA]. 

==See Also==
*[[Vascular Endothelial Growth Factor|Vascular Endothelial Growth Factor]]

==Reference==
<ref group="xtra">PMID:009634701</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Champe, M A.]]
[[Category: Christinger, H W.]]
[[Category: Fairbrother, W J.]]
[[Category: Keyt, B A.]]
[[Category: Starovasnik, M A.]]
[[Category: Angiogenesis]]
[[Category: Growth factor]]
[[Category: Heparin-binding]]