View source for 4ky0


==Crystal structure of a substrate-free glutamate transporter homologue from Thermococcus kodakarensis==
<StructureSection load='4ky0' size='340' side='right'caption='[[4ky0]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ky0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis_KOD1 Thermococcus kodakarensis KOD1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KY0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ky0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ky0 OCA], [https://pdbe.org/4ky0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ky0 RCSB], [https://www.ebi.ac.uk/pdbsum/4ky0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ky0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5JID0_THEKO Q5JID0_THEKO] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Archaeal glutamate transporter homologs catalyze the coupled uptake of aspartate and three sodium ions. After the delivery of the substrate and sodium ions to the cytoplasm, the empty binding site must reorient to the outward-facing conformation to reset the transporter. Here, we report a crystal structure of the substrate-free transporter GltTk from Thermococcus kodakarensis, which provides insight into the mechanism of this essential step in the translocation cycle.

Crystal structure of a substrate-free aspartate transporter.,Jensen S, Guskov A, Rempel S, Hanelt I, Slotboom DJ Nat Struct Mol Biol. 2013 Oct;20(10):1224-6. doi: 10.1038/nsmb.2663. Epub 2013, Sep 8. PMID:24013209<ref>PMID:24013209</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4ky0" style="background-color:#fffaf0;"></div>

==See Also==
*[[Symporter 3D structures|Symporter 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermococcus kodakarensis KOD1]]
[[Category: Guskov A]]
[[Category: Hanelt I]]
[[Category: Jensen S]]
[[Category: Rempel S]]
[[Category: Slotboom DJ]]