View source for 4bvc


==Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.==
<StructureSection load='4bvc' size='340' side='right'caption='[[4bvc]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BVC FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bvc OCA], [https://pdbe.org/4bvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bvc RCSB], [https://www.ebi.ac.uk/pdbsum/4bvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bvc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Althage M]]
[[Category: Andersson GMK]]
[[Category: Antonsson T]]
[[Category: Blaho S]]
[[Category: Bodin C]]
[[Category: Bostrom J]]
[[Category: Chen Y]]
[[Category: Dahlen A]]
[[Category: Eriksson PO]]
[[Category: Evertsson E]]
[[Category: Fex T]]
[[Category: Fjellstrom O]]
[[Category: Gustafsson D]]
[[Category: Hallberg C]]
[[Category: Hicks R]]
[[Category: Jarkvist E]]
[[Category: Johansson C]]
[[Category: Kalies I]]
[[Category: Kang D]]
[[Category: Kartberg F]]
[[Category: Knecht W]]
[[Category: Legnehed A]]
[[Category: Lindqvist AM]]
[[Category: Martinsson SA]]
[[Category: Moberg A]]
[[Category: Petersson AU]]
[[Category: Ridderstrom M]]
[[Category: Sandmark J]]
[[Category: Svalstedt Karlsson B]]
[[Category: Thelin A]]
[[Category: Tigerstrom A]]
[[Category: Vinblad J]]
[[Category: Xu B]]