4bvc

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Structural highlights

4bvc is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.6Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

APOA_HUMAN Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.^[1]

References

↑ Salonen EM, Jauhiainen M, Zardi L, Vaheri A, Ehnholm C. Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it. EMBO J. 1989 Dec 20;8(13):4035-40. PMID:2531657

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Salonen EM, Jauhiainen M, Zardi L, Vaheri A, Ehnholm C. Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it. EMBO J. 1989 Dec 20;8(13):4035-40. PMID:2531657

[1]

4bvc

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

4bvc

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

Structural highlights

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search