View source for 7qqd


==Nuclear factor one X - NFIX in P21==
<StructureSection load='7qqd' size='340' side='right'caption='[[7qqd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7qqd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QQD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qqd OCA], [https://pdbe.org/7qqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qqd RCSB], [https://www.ebi.ac.uk/pdbsum/7qqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qqd ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] Marshall-Smith syndrome;Malan overgrowth syndrome;19p13.3 microduplication syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NFIX_HUMAN NFIX_HUMAN] Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Bais G]]
[[Category: Chaves-Sanjuan A]]
[[Category: Demitri N]]
[[Category: Gourlay LJ]]
[[Category: Lapi M]]
[[Category: Nardini M]]
[[Category: Polentarutti M]]
[[Category: Tiberi M]]