View source for 6wgi


==Atomic model of the mutant OCCM (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation) loaded on DNA at 10.5 A resolution==
<StructureSection load='6wgi' size='340' side='right'caption='[[6wgi]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6wgi]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WGI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wgi OCA], [https://pdbe.org/6wgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wgi RCSB], [https://www.ebi.ac.uk/pdbsum/6wgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wgi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CDC6_YEAST CDC6_YEAST] Plays a crucial role in forming the pre-replicative complexes. Interacts with the origin recognition complex (ORC) and MCM2-7 helicase complex leading to the linking of those complexes and loading of the replicative helicase MCM2-7 onto the pre-replicative complexes. Required for the initiation of DNA replication and then actively participates in the suppression of nuclear division.<ref>PMID:10075735</ref> <ref>PMID:1600944</ref> <ref>PMID:23603117</ref> <ref>PMID:7641697</ref> <ref>PMID:8538771</ref> <ref>PMID:8978693</ref> <ref>PMID:9099949</ref> <ref>PMID:9312054</ref> <ref>PMID:9892652</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Bai L]]
[[Category: Dodd T]]
[[Category: Ivanov I]]
[[Category: Li H]]
[[Category: Magdalou I]]
[[Category: Riera A]]
[[Category: Schneider S]]
[[Category: Speck C]]
[[Category: Stillman B]]
[[Category: Yan C]]
[[Category: Yuan Z]]