View source for 6igs


==Crystal structure of HPRT from F. tularensis with Zinc==
<StructureSection load='6igs' size='340' side='right'caption='[[6igs]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6igs]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis Francisella tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IGS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6igs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6igs OCA], [https://pdbe.org/6igs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6igs RCSB], [https://www.ebi.ac.uk/pdbsum/6igs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6igs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5NI77_FRATT Q5NI77_FRATT] Purine salvage pathway enzyme which catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of hypoxanthine to yield IMP (inosine 5'-monophosphate). To a lesser extent, can also act on guanine leading to GMP, but shows a highly less efficient activity with xanthine.[ARBA:ARBA00003637]

==See Also==
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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</StructureSection>
[[Category: Francisella tularensis]]
[[Category: Large Structures]]
[[Category: Kundapura SV]]
[[Category: Pavithra GC]]
[[Category: Ramagopal UA]]