View source for 4fl6


==Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215==
<StructureSection load='4fl6' size='340' side='right'caption='[[4fl6]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4fl6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FL6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=UWN:[2-(PHENYLAMINO)BENZENE-1,4-DIYL]BIS{[4-(PYRROLIDIN-1-YL)PIPERIDIN-1-YL]METHANONE}'>UWN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fl6 OCA], [https://pdbe.org/4fl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fl6 RCSB], [https://www.ebi.ac.uk/pdbsum/4fl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fl6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LMBL3_HUMAN LMBL3_HUMAN] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Brown PJ]]
[[Category: Dong A]]
[[Category: Edwards AM]]
[[Category: Frye SV]]
[[Category: Graslund S]]
[[Category: Ingerman LA]]
[[Category: Ravichandran M]]
[[Category: Tempel W]]
[[Category: Zhong N]]