TRNase activity
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Some colicins, such as colicin 5, exhibit tRNase activity as their cytotoxic activity to kill the cell they target. This activity is aimed at the anticodon loops of the tRNA molecule, preventing the tRNA from being recognised in the ribosome. This then prevents the cell from producing proteins, and eventually leads to the death of the cell[1]. This is able to occur with just a single colicin molecule in the cell, following first order kinetics.
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| 2djh, resolution 1.90Å () | |||||||||
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| Related: | 2dfx | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
tRNase colicinstRNase colicins
ReferencesReferences
- ↑ Ogawa T, Inoue S, Yajima S, Hidaka M, Masaki H. Sequence-specific recognition of colicin E5, a tRNA-targeting ribonuclease. Nucleic Acids Res. 2006;34(21):6065-73. Epub 2006 Sep 8. PMID:16963495 doi:10.1093/nar/gkl629