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This Sandbox is Reserved from May 10, 2015, through July 31, 2015 for use by the class Protein 3D Structure Visualization & Structural Bioinformatics taught by Eric Martz and Keiichi Namba at Osaka University, Japan. This reservation includes Sandbox Reserved 1 through Sandbox Reserved 10. Syllabus.

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4HJE: CRYSTAL STRUCTURE OF P53 CORE DOMAIN IN COMPLEX WITH DNA4HJE: CRYSTAL STRUCTURE OF P53 CORE DOMAIN IN COMPLEX WITH DNA

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This protein (celluler tumor antigen p53) is known as a tumor suppressor.

So, this protein contact DNA.

The regions contacting DNA are .

are important for sequence-specific binding.

Lys 120, Arg 280 contact major groove, and Arg 248 contacts minor groove.