Ribosomal protein S3

Function

Ribosomal protein S3 (RPS3) is one of the 21 proteins which belong to the 30S of the bacterial ribosome or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. The eukaryote 40S small subunit contains 30 proteins. It is known to be involved in the binding of initiator tRNA fMet^[1].

Relevance

RPS3 is secreted in cancer cells thus it is an indicator of malignant tumors^[2]. RPS3 linked to a leader peptide could be potential therapeutic agent against Alzheimer disease^[3].

3D Structures of ribosomal protein S33D Structures of ribosomal protein S3

Updated on 29-September-2017

1wh9 – RPS3 KH domain – human
4bsz – RPS3 + Yar1 – yeast

ReferencesReferences

↑ Yadavilli S, Mayo LD, Higgins M, Lain S, Hegde V, Deutsch WA. Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain. DNA Repair (Amst). 2009 Oct 2;8(10):1215-24. doi: 10.1016/j.dnarep.2009.07.003., Epub 2009 Aug 4. PMID:19656744 doi:http://dx.doi.org/10.1016/j.dnarep.2009.07.003
↑ Kim Y, Kim HD, Youn B, Park YG, Kim J. Ribosomal protein S3 is secreted as a homodimer in cancer cells. Biochem Biophys Res Commun. 2013 Nov 29;441(4):805-8. doi:, 10.1016/j.bbrc.2013.10.132. Epub 2013 Nov 5. PMID:24211576 doi:http://dx.doi.org/10.1016/j.bbrc.2013.10.132
↑ Ahn EH, Kim DW, Shin MJ, Kim YN, Kim HR, Woo SJ, Kim SM, Kim DS, Kim J, Park J, Eum WS, Hwang HS, Choi SY. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. Free Radic Biol Med. 2013 Feb;55:36-45. doi: 10.1016/j.freeradbiomed.2012.11.008., Epub 2012 Nov 23. PMID:23178948 doi:http://dx.doi.org/10.1016/j.freeradbiomed.2012.11.008

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Alexander Berchansky, Wayne Decatur, Michal Harel

[1] Yadavilli S, Mayo LD, Higgins M, Lain S, Hegde V, Deutsch WA. Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain. DNA Repair (Amst). 2009 Oct 2;8(10):1215-24. doi: 10.1016/j.dnarep.2009.07.003., Epub 2009 Aug 4. PMID:19656744 doi:http://dx.doi.org/10.1016/j.dnarep.2009.07.003

[2] Kim Y, Kim HD, Youn B, Park YG, Kim J. Ribosomal protein S3 is secreted as a homodimer in cancer cells. Biochem Biophys Res Commun. 2013 Nov 29;441(4):805-8. doi:, 10.1016/j.bbrc.2013.10.132. Epub 2013 Nov 5. PMID:24211576 doi:http://dx.doi.org/10.1016/j.bbrc.2013.10.132

[3] Ahn EH, Kim DW, Shin MJ, Kim YN, Kim HR, Woo SJ, Kim SM, Kim DS, Kim J, Park J, Eum WS, Hwang HS, Choi SY. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. Free Radic Biol Med. 2013 Feb;55:36-45. doi: 10.1016/j.freeradbiomed.2012.11.008., Epub 2012 Nov 23. PMID:23178948 doi:http://dx.doi.org/10.1016/j.freeradbiomed.2012.11.008

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