Ribosomal protein S2

Function

Ribosomal protein S2 (RPS2) is one of the 21 proteins which belong to the 30S small subunit of the bacterial ribosome or the 30 proteins which belong to the 40S small subunit of the eukaryotic ribosome. Its N-terminal is rich in Arg-Gly repeats and has two RGGF copies which are believed to be associated with nuclear localization and binding to RNA. In archaea the protein is called S2P (RPS2P).

Relevance

RPS2 is a tumor antigen recognized by antibodies. Thus its peptide can be suitable for use in immunotherapy for HLA-A26+ cancer patients^[1]. RPS2 is over expressed in liver cancer^[2].

3D Structures of Ribosomal protein S23D Structures of Ribosomal protein S2

Updated on 31-December-2017

1vi5, 1vi6 – RPS2P – Archaeoglobus fulgidus
1x18 – RPS2 + RPS7 + RPS11 + RPS18 + GTP-binding protein + RNA – Thermus thermophilus – Cryo EM
4toi – RPS2/RPS1 N-terminal – Escherichia coli

ReferencesReferences

↑ Koga M, Shichijo S, Yamada A, Ashihara J, Sawamizu H, Kusukawa J, Itoh K. Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. Tissue Antigens. 2003 Feb;61(2):136-45. PMID:12694581
↑ Kowalczyk P, Woszczynski M, Ostrowski J. Increased expression of ribosomal protein S2 in liver tumors, posthepactomized livers, and proliferating hepatocytes in vitro. Acta Biochim Pol. 2002;49(3):615-24. PMID:12422231 doi:http://dx.doi.org/024903615

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Alexander Berchansky, Wayne Decatur, Michal Harel, Joel L. Sussman

[1] Koga M, Shichijo S, Yamada A, Ashihara J, Sawamizu H, Kusukawa J, Itoh K. Identification of ribosomal proteins S2 and L10a as tumor antigens recognized by HLA-A26-restricted CTL. Tissue Antigens. 2003 Feb;61(2):136-45. PMID:12694581

[2] Kowalczyk P, Woszczynski M, Ostrowski J. Increased expression of ribosomal protein S2 in liver tumors, posthepactomized livers, and proliferating hepatocytes in vitro. Acta Biochim Pol. 2002;49(3):615-24. PMID:12422231 doi:http://dx.doi.org/024903615

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