Ribosomal protein L16

Function

Ribosomal protein L16 (RPL16) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It binds to 23S RRNA and is located at the A site of the peptidyltransferase center^[1].

Relevance

Mutations in RPL16 confer reduced susceptibility to the antibiotic evernimicin^[2].

3D Structures of Ribosomal protein L163D Structures of Ribosomal protein L16

Updated on 01-October-2017

ReferencesReferences

↑ Nishimura M, Yoshida T, Shirouzu M, Terada T, Kuramitsu S, Yokoyama S, Ohkubo T, Kobayashi Y. Solution structure of ribosomal protein L16 from Thermus thermophilus HB8. J Mol Biol. 2004 Dec 10;344(5):1369-83. PMID:15561149 doi:10.1016/j.jmb.2004.10.011
↑ Adrian PV, Zhao W, Black TA, Shaw KJ, Hare RS, Klugman KP. Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action. Antimicrob Agents Chemother. 2000 Mar;44(3):732-8. PMID:10681347

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Nishimura M, Yoshida T, Shirouzu M, Terada T, Kuramitsu S, Yokoyama S, Ohkubo T, Kobayashi Y. Solution structure of ribosomal protein L16 from Thermus thermophilus HB8. J Mol Biol. 2004 Dec 10;344(5):1369-83. PMID:15561149 doi:10.1016/j.jmb.2004.10.011

[2] Adrian PV, Zhao W, Black TA, Shaw KJ, Hare RS, Klugman KP. Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action. Antimicrob Agents Chemother. 2000 Mar;44(3):732-8. PMID:10681347

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