Purine nucleoside phosphorylase

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Function

Purine nucleoside phosphorylase (PNP) cleaves nucleosides by phosphorylating ribose to produce ribose-1-phosphate. PNP metabolizes adenosine, inosine and guanosine[1]. PNP metabolizes the waste molecules deoxyinosine and deoxyguanosine which are formed when DNA breaks down.

Disease

PNP deficiency results in severe combined immunodeficiency[2].

Structural highlights

. The ribose binding site is composed of mostly hydrophobic side chains[3]. .

3D structures of purine nucleoside phosphorylase

Purine nucleoside phosphorylase 3D structures


Human purine nucleoside phosphorylase complex with guanine and sulfate (PDB entry 1v2h)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349-425. PMID:11337031
  2. ↑ Markert ML. Purine nucleoside phosphorylase deficiency. Immunodefic Rev. 1991;3(1):45-81. PMID:1931007
  3. ↑ de Azevedo WF Jr, Canduri F, dos Santos DM, Pereira JH, Bertacine Dias MV, Silva RG, Mendes MA, Basso LA, Palma MS, Santos DS. Crystal structure of human PNP complexed with guanine. Biochem Biophys Res Commun. 2003 Dec 19;312(3):767-72. PMID:14680831 doi:10.1016/j.bbrc.2003.10.190

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