Poly (ADP-ribose) glycohydrolase

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Function

Poly (ADP-ribose) glycohydrolase (PARG) hydrolizes the ribose-ribose bonds in poly (ADP-ribose). Poly (ADP-ribose) are synthesized after DNA damage. PARG acts as both endo- and exoglycosidase and releases poly (ADP-ribose) of different lengths including monomers[1].

Relevance

PARG deficiency leads to cell death. Over-activation of PARP due to oxidative stress culminates in cell dysfunction and necrosis. PARP inhibitors have anti-inflammatory effect[2].

Structural highlights

The of PARG contains [3]. Water molecules are shown as red spheres.

3D Structures of poly (ADP-ribose) glycohydrolase

Poly(ADP-ribose) glycohydrolase 3D structures


Structure of human poly (ADP-ribose) glycohydrolase catalytic domain complex with ADP-ribose (PDB code 3sig).

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Herceg Z, Wang ZQ. Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death. Mutat Res. 2001 Jun 2;477(1-2):97-110. PMID:11376691
  2. ↑ Virag L, Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev. 2002 Sep;54(3):375-429. PMID:12223530
  3. ↑ Slade D, Dunstan MS, Barkauskaite E, Weston R, Lafite P, Dixon N, Ahel M, Leys D, Ahel I. The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase. Nature. 2011 Sep 4. doi: 10.1038/nature10404. PMID:21892188 doi:10.1038/nature10404

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