Paracrine signaling

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Paracrine signaling is a form of cell signaling, a type of cellular communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action). The highly conserved receptors and pathways can be organized into four major families based on similar structures: fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily.

Crystal structure of XWnt8 (green) in complex with the cysteine-rich domain of Frizzled 8 (deep sky blue)

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Alexander Berchansky