Oxaloacetate/aspartate: lysine, asparagine, methionine, threonine, and isoleucine

The oxaloacetate/aspartate family of amino acids is composed of lysine, asparagine, methionine, threonine, and isoleucine. Aspartate can be converted into lysine, asparagine, methionine and threonine. Threonine also gives rise to isoleucine. The associated enzymes are subject to regulation via feedback inhibition and/or repression at the genetic level. As is typical in highly branched metabolic pathways, additional regulation at each branch point of the pathway. The biosynthesis of aspartate frequently involves the transamination of Citric Acid Cycle intermediate . See also: Amino Acid Synthesis

spinqualitylabelsall models E. coli aspartate aminotransferase complex with PLP and sulfate (PDB code 1asn) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image