Neutrophil gelatinase-associated lipocalin

Function Neutrophil gelatinase-associated lipocalin (NGAL) or lipocalin-2 is involved in innate immunity by sequestering bacterial iron and thus preventing bacterial growth. Lipocalin-1 (Lcn1) or Tear lipocalin is a major protein in tears which binds diverse set of lipophilic molecules . Relevance NGAL is secreted in high levels into the blood following acute kidney injury and thus can be used as a biomarker for it. Lcn1 functions in tears includes their viscosity and it serves as biomarker for dry eyes. Structural highlights like carboxymycobactin or enterobactin. Water molecules are shown as red spheres.

spinqualitylabelsall models Structure of human neutrophil gelatinase-associated lipocalin complex with Fe+3 ion and Siderophores (PDB code 1x71). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of neutrophil gelatinase-associated lipocalin3D structures of neutrophil gelatinase-associated lipocalin

Updated on 16-July-2023

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• Neutrophil gelatinase-associated lipocalin
  • 1dfv, 1qqs, 3bx8, 6gqz, 6z6z – hNGAL – human
    
  • 3dtq, 5jr8, 5mhh, 6o5d, 6qmu – hNGAL (mutant)
    
  • 1ngl – hNGAL - NMR
    
  • 2k23 – NGAL – rat - NMR
    
  • 3s26 – mNGAL – mouse
    
• Neutrophil gelatinase-associated lipocalin complex
  • 1l6m – hNGAL (mutant) + Fe+3
    
  • 5khp, 5kic, 5kid – hNGAL + actinide
    
  • 3pec, 3ped – hNGAL + Fe+3 + carboxymycobactin
    
  • 1x71, 1x89, 1x8u – hNGAL (mutant) + Fe+3 + carboxymycobactin
    
  • 3by0, 3cbc, 3cmp, 3hwd, 3hwf, 3hwg, 3i0a, 3k3l, 3t1d, 3u0d, [6o5d]] – hNGAL (mutant) + Fe+3 + enterobactin
    
  • 4zfx – hNGAL + actinide + enterobactin
    
  • 4k19 – hNGAL (mutant) + Fe+3 + fluvibactin
    
  • 3tf6 – hNGAL (mutant) + Eu+2+ enterobactin
    
  • 6gr0 – hNGAL + Ga+3 + oxidanyl derivative
    
  • 3fw4, 3fw5 – hNGAL (mutant) + Fe+3 + catechol derivative
    
  • 5nkn – hNGAL + colchicine
    
  • 4zhc – hNGAL + actinide + pyridine derivative
    
  • 4zhd – hNGAL (mutant) + actinide + benzoyl derivative
    
  • 4zhf, 4zhg, 4zhh – hNGAL (mutant) + actinide +pyridine derivative
    
  • 3cmp, 3hwe – hNGAL (mutant) + Fe+3 + bishacam
    
  • 3dsz – hNGAL + Yt+3 + DTPA
    
  • 4iaw, 4iax – hNGAL (mutant) + Yt+3 + DTPA
    
  • 3tzs – hNGAL (mutant) + phenylurea
    
  • 4gh7, 5n47, 5n48 – hNGAL (mutant) + fibronectin
    
  • 4qae – hNGAL (mutant) + hepcidin
    
  • 3bx7 – hNGAL + CTLA-4
    
  • 6z2c – hNGAL + transition state analog
    
  • 4mvi, 4mvk, 4mvl – hNGAL (mutant) + beta-APP40
    
  • 6s8v – hNGAL + h4F2HC
    
  • 6sua – hNGAL (mutant) + m4F2HC
    
  • 3u9p – mNGAL + antibody
    
• Lipocalin-1 (Lcn1)
  • 4qaf – hLcn1 + VEGF-A
    
  • 1xki – hLcn1 (mutant) + Zn
    
  • 3eyc – hLcn1 (mutant) + butanediol