Microtubule-associated serine/threonine kinase

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Function

Microtubule_associated serine/threonine kinase (MAST) belongs to a family of proteins which contain a serine/threonine kinase domain and a PDZ domain.

  • MAST1 associates with the cytoskeleton and can bind through its PDZ domain both β-2-synthrophin and neuronal nitric oxide synthase.
  • MAST2 regulates lipopolysaccharide-induced IL-12 synthesis.
  • MAST L supports mitosis by phosphorylating PP2A/B55[1]


Human Microtubule_associated serine/threonine kinase 1 PDZ domain complex with imidazole and ethylene glycol (PDB code 3ps4)

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3D Structures of microtubule-associated serine/threonine kinase3D Structures of microtubule-associated serine/threonine kinase

Updated on 11-July-2024

ReferencesReferences

  1. ↑ Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martínez-Alonso D, González-Martínez J, Santiveri C, Campos-Olivas R, Ximénez-Embún P, Muñoz J, Álvarez-Fernández M, Malumbres M. The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. EMBO J. 2023 Jan 16;42(2):e110833. PMID:36354735 doi:10.15252/embj.2022110833

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Michal Harel, Joel L. Sussman
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